Ingredients/Content

Lopinavir 200mg Ritonavir 200mg

Efficacy/effectiveness

This combination product contains two drugs, lopinavir and ritonavir. This product is used in conjunction with other HIV drugs to control HIV infection. It helps to reduce the amount of HIV in the body so that the immune system can work better. This lowers the probability of developing HIV complications, such as new complications, cancer, and improves the quality of life. Both lopinavir and ritonavir fall into the category of drugs known as HIV protease inhibitors. Litonavir increases the level of lopinavir. This helps lopinavir work better.

Lopinavir / ritonavir is not a cure for HIV infection. To reduce the risk of transmitting HIV disease to others, do the following. 

(1) Continue taking all HIV medications as prescribed by your doctor. 

(2) Always use effective barrier methods in all sexual activities (latex or polyurethane condoms)

(3) Do not share personal items that may reach blood or other bodily fluids (e.g., needles/cynials, toothbrushes, and razors). Consult your doctor or pharmacist for more information.

Usage/capacity

1. Adult 

For the standard recommended usage, this approximately 400 mg/100 mg is taken with or without food twice a day. For adult patients who are deemed to require single-daily use, 800 mg/200 mg can be taken with or without food once a day. Single-daily use is limited to adult patients with very few mutations associated with protease inhibitor (PI) (e.g., fewer than three PI mutations, consistent with clinical trial results). And the fact that single-daily use has a lower sustainability for virus suppression and a higher risk for diarrhea compared to standard double-daily use should be taken into account. This drug should not be administered as a once-daily regimen when administered in combination with epabyrens, nevirafine, amprenavir, or nelfinavir. Lopinavir/ritonavir dose control during pregnancy or after childbirth is not required, and single-daily regimen is not recommended for pregnant women.

Read the medication guide and the patient information guide provided by the pharmacist, if possible, before starting taking lopinavir / ritonavir and whenever refilling. If you have any questions, please contact your doctor or pharmacist.

Do not break, break, or chew the tablet.

Doses are based on your health status, your response to treatment, and any other medication you are taking. Inform your doctor and pharmacist about any products you use (including prescription drugs, non-prescription drugs, and herbal products).

2. Children

Doses are based on age, weight, and height. A single daily dose of this drug is not recommended for children under the age of 18.

If you take didanosine in addition to this product, you can take it at the same time as this product, but you can take it without food.

It is very important to continue taking this medication (and other HIV medications) as prescribed by your doctor. Do not skip the dose.

Take this medicine at regular intervals for the best effect. Take this medicine at the same time every day to help you remember.

Take more or less medication than prescribed, or stop taking it even for a short time (or other HIV medications), unless instructed by your doctor. Doing so can increase the amount of virus, make the infection difficult to treat, or worsen the side effects.

Side effects

Diarrhea, nausea, vomiting, upset stomach, gas, headache, and sleep disorders can occur. If these effects persist or worsen, notify your doctor or pharmacist immediately.

Remember, the doctor prescribed you this drug because he determined that the benefits outweigh the risk of side effects. Many people who use this drug have no serious side effects.

Symptoms can also occur if the immune system overreacts. This reaction can occur at any time (after or months after starting HIV treatment). Severe symptoms such as unexplained weight loss, severe fatigue, lingering muscle pain / weakness, headache, joint pain, and paralysis should be sought immediately for medical attention. Hand / foot / arm / leg, vision change, signs of infection (fever, chills, swollen lymph nodes), shortness of breath, cough, and unhealing skin inflammation), irritable thyroid symptoms (hyperactivity, nervousness, fever intolerance, fast / wrinkle / irregular heartbeat, swollen eyes, abnormal growth of the throat / thyroid gland known as thyroidoma) are the symptoms of Guillain-Barre syndrome.

Precautions for use

Before taking this product, inform your doctor or pharmacist if you are allergic to lopinavir or ritonavir. Or if you have other allergies. This product contains inactive ingredients, which can cause allergic reactions or other problems. Consult your pharmacist for more information.

Prior to this use: medication to the doctor, especially in severe cases, including pharmacist liver disease, diabetes, pancreatitis, high blood fat levels (cholesterol/neutral fat), heart problems (coronavirus disease, cardiac arrest, etc.) hemophilia), prior infection by certain diseases (hepatitis B infection, hepatitis C infection, tuberculosis).

Lopinavir / ritonavir can cause conditions that affect the heartbeat (QT prolongation). QT prolongation can hardly immediately cause a severe (almost fatal) fast / irregular heartbeat and other symptoms (severe dizziness, fainting).

The risk of QT prolongation may increase if you have a specific health condition or if you take other drugs that may cause QT prolongation. Inform your doctor or pharmacist about any medication you take before using lopinavir/ritonavir, and in the following conditions: certain heart problems (cardiac failure, slow heartbeat, QT prolongation in ECG), and family history of certain heart problems (QT prolongation in electrocardiogram, sudden heart death).

Low levels of potassium or magnesium in the blood can increase the risk of QT prolongation. This risk can increase the risk of using certain drugs (such as diuretics / "water pills") or consult your doctor about the safe use of lopinavir / ritonavir if you have conditions such as severe sweating, diarrhea, or vomiting.

Before surgery, inform your doctor or dentist about all products (including prescription drugs, non-prescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation.

Before using this medication, tell your doctor if you are pregnant. Treatment reduces the risk of transmitting HIV to your baby. Discuss the risks and benefits with your doctor.

We don't know if this drug is delivered to breast milk. Do not breastfeed because breast milk can transmit HIV.

Storage method

Store in the original container at room temperature without light and moisture. 

Do not store this product outside the container for more than 2 weeks, especially in humid areas. 

Do not store it in the bathroom. 

Do not store it out of reach of children and pets.