Efficacy/effectiveness

Flagyl is used for the prevention and treatment of infections with identified or suspected causes of anaerobic bacteria.

Flagyl is active against a wide range of pathogenic microorganisms, especially Bacteroides, Fusobacteria, Clostridia, Eubacteria, anaerobes, and Gardnerella vaginalis species.

It is also active against Trichomonas, Entamoeba histolytica, Giardia lamblia, and Balantidium coli.

Flagyl is indicated by the following signs in adults and children.

1. Prevention of postoperative infections due to anaerobic bacteria, especially Bacteroidetes and anaerobic streptococcal species.

2. Treatment of postoperative wound infections with sepsis, bacteremia, peritonitis, brain abscess, necrotizing pneumonia, osteomyelitis, postpartum sepsis, pelvic abscess, pelvic cellulitis, and pathogenic anaerobic bacteria isolated.

3. urogenic trichomoniasis in women and men.

4. Bacterial vaginitis (also known as non-specific vaginitis, anaerobic vaginitis, or Gardnerella vaginitis).

5. All forms of amebiasis (cystic communicators without intestinal and extraintestinal diseases and symptoms).

6. Giardia.

7. acute ulcerative gingivitis.

8. Anaerobic infected leg ulcers and bedsores.

9. Acute dental infection (e.g., acute perivascularization and acute apical infection).

Usage/capacity

The use of metronidazole according to the formulation, indication, and purpose of use is as follows.

– treatment of trichomoniasis

250 mg once, twice a day, for 10 days

– treatment of anaerobic infections

500 mg once, 3 to 4 times a day, 7 to 10 days (maximum daily dose: 4g)

postoperative prevention

First take 1g, then take 250mg once, then take 3 times a day 

– treatment of amebiasis

500-750mg at a time, 3 times a day, 5-10 days.

Packaging unit

540 tablets

Ingredients/Content

Active ingredients: 400 mg of metronidazole in 1 tablet

Precautions for use

– In patients with liver disorders, the metabolism of metronidazole may slow down and blood concentration may increase, so it is carefully administered.

– There is a risk of confusion, drowsiness, hallucinations, convulsions, or temporary visual impairments, so do not drive or manipulate the machine if these symptoms appear.

Regular clinical tests are recommended because germ cells may be damaged when administered for more than 10 days.

– Dark red urine may appear due to metabolites of metronidazole.

– If you take a high dose, you may not show symptoms even if you are infected with syphilis (sexually transmitted infectious disease), so patients with potential syphilis infection should be careful.

– Patients with renal impairment should be careful when taking metronidazole tablets. 

Side effects

– Common side effects (reported by more than 10% of users) headache, nausea, vaginitis, etc

– Common side effects (reported in 1 to 10% of users) such as abdominal pain, diarrhea, dizziness, urination disorders, etc

– Rare side effects (reported by less than 1% of users) or unidentified side effects

Aseptic meningitis, convulsions, depression, confusion, hallucinations, peripheral neuropathy, seizures, flushing, rash, Stevens-Johnson syndrome, riel syndrome, protrusion, loss of appetite, pancreatitis, stomatitis, vomiting, urinary discoloration (dark urine), cystitis, leukopenia, neutropenia, thrombocytopenia, elevated hepatic enzyme levels, jaundice, anaphylaxis, fever, etc  

Manufacturer

Abbott