Efficacy/effectiveness

1. Treatment of liver fluke, pulmonary fluke and schistosome infections

2. Treatment of various pest infections such as Asteroid, Asteroid, South American fish, and Dwarf

Usage/capacity

1) Since the composition has a slight bitter taste, it is better to take it quickly with water without chewing the tablet. In particular, when taking tablets in installments for volume control, it is better to take them after meals. When taking it repeatedly several times a day, the administration interval for each dose should not be less than 4 hours and not more than 6 hours. 

2) It is elongated with three dividing lines so that the dose can be accurately adjusted according to the patient's weight, and each of the four pieces by the dividing line contains 150 mg of active substances. If a quarter of the tablet is required, it can be easily used by pressing the dividing line with the fingernail of the thumb from the end of the tablet to cut it.

Side effects

The main side effects have been reported as headache, flushing, facial flushing, indigestion, back pain, muscle pain, stuffy nose, and limb pain. If you notice these symptoms, consult your doctor or pharmacist. It is possible that this is an initial symptom of the side effects of the indication in [], which rarely shows the following symptoms. In this case, stop using it and seek medical attention immediately. The side effects beyond the rash, swelling of the face, inflammation of the lips and mouth and conjunctiva [hypersensitivity] are not all described. If you have symptoms that concern you other than the above, consult your doctor or pharmacist. 

Precautions for use

Dizziness or vision impairment (e.g., eye Kasumi) may occur, so be careful when operating dangerous machines, such as working on high ground or driving a car. Please refrain from grapefruit juice because it can enhance the action of medicine and strengthen the side effects. 

1. Do not administer it to the following patients. Patients who are hypersensitivity to this drug and its components

2. Careful administration should be given to the following patients: 1) renal dysfunction 2) moderate or higher liver dysfunction patients 3) heart failure patients requiring digitalization 4) arrhythmia patients

3. Abnormal reactions 1) Rarely, fatigue, headache, dizziness, diarrhea accompanied by bleeding sometimes, and abdominal discomfort accompanied by nausea may appear. 2) Rarely, arrhythmia such as bradycardia, isoarrhythmia, ventricular fibrillation, and atrioventricular block may appear. 3) Very rarely, skin itchiness (flabbergines) and body temperature rise may occur. 4) Blood test changes such as decreased red blood cells, decreased platelets, increased eosinophils, and increased white blood cells may occur.

4. General Caution 1) Abnormal reactions may occur more often in patients who have received a dose of about 40 mg per kg of body weight at a time. 2) Abnormal reactions can occur frequently or severely in patients with large amounts of parasites. 3) Even in patients with abnormal drug metabolism due to abnormal liver function caused by cerebrospinal schistosomiasis infection, additional attention is not needed because the adverse reactions caused by this do not increase further. 4) Since cranial cystosis requires hospital treatment by a specialist, special attention is needed in areas known to have human cystosis. 5) Since drowsiness may be accompanied, be careful when operating a machine or driving a car.

5. Interaction 1) When taken in combination with anticonvulsants such as phenytoin, phenobarbital, and carbamazepine, or drugs that promote metabolism by cytochrome P450, such as dexamethasone, the blood concentration of this drug may be lowered. In particular, rifampin has a strong action, so it is desirable to avoid co-administration. 2) When taken in combination with drugs that inhibit metabolism by cytochrome P450, such as cimetidine, ketoconazole, itraconazole, and erythromycin, the blood concentration of this drug may increase.

6. Administration to pregnant and lactating women 1) This drug did not show any toxic effect on the mother or fetus in animal testing. However, it is advisable to avoid taking it during the first three months of pregnancy in accordance with the general principle of restricting the use of the drug during pregnancy. 2) Since this drug can be transferred to breast milk, breastfeeding should be stopped until 72 hours after treatment.

7. The safety of infants and toddlers under the age of 4 years of administration to children has not been established.

8. Treatment in case of overdose A quick-acting laxative is administered when overdose is administered.

Storage method

Preserving room temperature, airtight container